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KMID : 0366220050400040261
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Korean Journal of Hematology
2005 Volume.40 No. 4 p.261 ~ p.265
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A Case of Multiple Myeloma Presenting as Non-obstructive Jaundice Due to Plasma Cell Infiltration of the Liver
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Yu Mi-Hyun
Kim Hyun-Woo
Yeo Young-Sun
Lim Jeong-Woo
Jeong Woo-Jin
Han Eun-Mee
Suh Chul-Won
Kim Soon-Bae
Park Su-Kil
Lee Sang-Koo
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Abstract
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Extraosseous manifestations are found in less than 5% of the patients with multiple myeloma. We reported here on a rare case of multiple myeloma presenting as non-obstructive jaundice due to diffuse plasma cell infiltration of the liver. A 70-year-old man was referred to our hospital because of general weakness, weight loss, jaundice, anemia and proteinuria. The laboratory studies showed: hemoglobin 8.5g/dL, calcium 10.3mg/dL, creatinine 1.3mg/dL, AST 41IU/L, ALT 26IU/L, alkaline phosphatase 304IU/L, total bilirubin 4.0mg/dL, direct bilirubin 2.3mg/dL and 24 hour urinary protein 1,120mg. The serologic tests for hepatitis B and C virus were negative. The abdominal CT scans were normal. The urinary protein studies revealed a M component of the lamda type light chain. The bone marrow biopsy showed atypical plasma cells, and the liver biopsy showed a diffuse sinusoidal infiltration of plasma cells.
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KEYWORD
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Multiple myeloma, Plasma cell infiltration, Jaundice, Liver
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